The Catholic Church’s Magisterium deems as devoid of moral lawfulness gamete and embryo donation. The history of In vitro fertilization (IVF) pioneers perfectly shows how Catholic moral prohibitions have worked, as well as the origins of the French bioethical system. This system interpreted the medical and social practice of gamete donation through the lens of the concept of “don de couple à couple”, trying to address moral prohibitions. Nevertheless, in 2020 the bioethics law reform might change, fundamentally, this system.